Previously, the combination of CK18-Asp396 apoptotic fragment and Fibroscan improved their diagnostic performance for the detection of significant and advanced fibrosis in NAFLD [13] and a new scoring system for predicting NASH using the combination of this fragment with the FIB-4 index demonstrated a high predictive accuracy for the presence of liver fibrosis [14]. This evidence concerns the gene KRT18 and fibrosis.