Here, we demonstrated that p300 was involved in the induction of ALOX15/15B expression by cortisol in human amnion fibroblasts, which is consistent with previous studies showing the involvement of p300 in the regulation of ALOX15/15B expression in A549 lung epithelial cells and SH-SY5Y human neuroblastoma cells [68,69]. This evidence concerns the gene EP300 and neuroblastoma.