In PF, fibrotic lung remodeling is driven by the TGF-β1-mediated inflammatory response, where TGF-β induction was through an AIM2-activated caspase-4 dependent manner (noncanonical inflammasome) but not via a caspase-1- or TLR4-dependent pathway. Here, TGFB1 is linked to pemphigus foliaceus.