Similar to GVBs observed in the brains of tauopathy patients, GVBs in this spontaneously aggregating tau model present as vesicular structures with a membrane positive for lysosomal integral membrane protein 2 that contain a dense core immunopositive for casein kinase 1 δ (CK1δ) and other typical GVB markers [25]. Here, MAPT is linked to tauopathy.