To circumvent this, we recently implemented a tau variant that combines FTDtau1 with an additional FTD mutation (P301L+S320F; FTDtau1+2) that has been shown to induce spontaneous pathological tau accumulation in mice in vivo [23] and ex vivo [24] to develop a novel GVB model in mouse primary neurons [25]. This evidence concerns the gene MAPT and frontotemporal dementia.