MAPT and frontotemporal dementia: Our lab reported the first primary neuron model for GVBs using viral transduction of human tau with the P301L FTD mutation fused to a green fluorescent protein (GFP) tag (FTDtau1-GFP) that forms intraneuronal aggregates upon the addition of exogenous tau pre-formed fibrils (PFFs) or seeds [17].