CXCL10 and clear cell adenocarcinoma: Moreover, Ardighieri et al. [110] have shown that, in most cases of clear cell carcinomas (CCC) that demonstrate poor prognosis and resistance to platinum-based chemotherapy, the high density of TAMs is related to poor T cell infiltration as a result of C-X-C motif chemokine ligand 10 (CXCL10) produced by M1-type macrophages.