When studying the functions carried out by genes overexpressed in HD at six weeks, we observed that several functions implicitly related to neurodegeneration, linked to genes such as Adora2a, Gm12695, and Creb3, are enriched, which somehow is unexpected given that six week old mice do not yet show evident symptoms of HD; however, it has been described that symptoms increase with age [37]. Here, ADORA2A is linked to Huntington disease.