CD8A and obesity due to melanocortin 4 receptor deficiency: To confirm findings from these large consortia data, sorted CD8+, CD14+ PBMCs and serum of patients treated at our institute were utilized for paired metabolomics (serum) and transcriptomics (PBMCs) to reveal the convergence of metabolic dysregulation both in the context of obesity and sex (Supplementary Figure S4B).