DEGS1 and cancer: The other enzymes involved in the de novo S1P synthesis, dihydroceramide desaturase 1 and 2 (DEGS1 and DEGS2), did not differ between the groups considered (non-cancerous male vs. non-cancerous female and cancerous male vs. cancerous female; Supplementary Figure S6A–D; A. Non-cancer DEGS1 mean expression: male 1.073 and female 1.094 p = 0.32; B. Cancer DEGS1 mean expression: male 1.06 and female 1.052 p = 0.63; C. Non-cancer DEGS2 mean expression: male −0.0339 and female 0.047 p = 0.31; D. Cancer DEGS2 mean expression: male −0.224 and female −0.215 p = 0.84).