To rule out the different levels of plasma S1P being related to its dephosphorylation by means of sphingosine-1-phosphate phosphatases (SGPP1 and SGPP2, enzymes that convert S1P into sphingosine), or its degradation by means of sphingosine-1-phosphate lyase (SGPL1, an enzyme that degrades S1P into hexadecenal and phosphoethanolamine), we evaluated these enzyme transcript levels in lung cancer tissues. This evidence concerns the gene SGPL1 and lung cancer.