The transcripts expression of these enzymes did not differ in non-cancerous tissues of both males and females (Supplementary Figure S7A,C,E; A. Non-cancer SMPD1 mean expression: male 0.913 and female 0.893 p = 0.45; C. Non-cancer SMPD2 mean expression: male 0.356 and female 0.333 p = 0.46; E. Non-cancer SMPD3 mean expression: male 0.208 and female 0.187 p = 0.75). This evidence concerns the gene SMPD1 and cancer.