EP300 and acute myeloid leukemia: Similarly, in acute myeloid leukemia, BRD4 has been shown to co-localize and synergistically interact with hematopoietic TFs (including PU.1, FLI1, ERG, C/EBPα, C/EBPβ, and MYB) combined with lysine acetyltransferase p300/CBP to support specific transcriptional circuits in this disease [32].