YM155 inhibited survivin expression, activated the caspase pathway and reduced the viability of ovarian cancer cells (Figure 4a,b), suggesting that the endogenous expression of survivin in ovarian cancer cells was required to prevent them from undergoing apoptosis and that domatinostat induced apoptosis in ovarian cancer cells by targeting survivin expression. The gene discussed is BIRC5; the disease is ovarian carcinoma.