SMAD3 and neoplasm: LINC01977 is upregulated and correlated with poor prognosis in lung adenocarcinoma [58] and breast cancer [59]; in lung adenocarcinoma, TGF-β derived from infiltrated tumor-associated macrophages (TAM2) activates SMAD3, which binds LINC01977 to induce its nuclear transport, where it upregulates transcription by simultaneously binding the promoter and super-enhancer, facilitating the interaction between SMAD3 and CBP/P300 to activate ZEB1 transcription [58].