SMAD2 and breast cancer: ENSG00000285756 is downregulated in cervical cancer [63], and TFAP2A-AS1 is downregulated and correlated with a good prognosis in breast cancer, acting in vitro as a tumor suppressor by sponging miR-933 to modulate SMAD2 mRNA stability [64]; TFAP2A-AS1 is also transcriptionally activated by KLF15 and inhibits the proliferation and migration of gastric cancer cells by sponging miR-3657 to regulate NISCH mRNA stability [65].