Blocking the glutamate decarboxylase enzyme, which is responsible for GABA generation from glutamate, and the SLC1A2 transporter, which is responsible for glutamate uptake, or boosting the GABA transaminase enzyme, which is responsible for GABA metabolism, and the astrocytic SLC6A1 transporter, which is the crucial brain GABA transporter that is responsible for GABA uptake, cause epilepsy [1,16,35,39]. Here, ABAT is linked to epilepsy.