WEE1 and tuberous sclerosis: The protein kinase mTOR (mechanistic target of rapamycin) is involved in many regulatory and proliferation mechanisms, forming two different complexes called mTOR complex 1 and mTOR complex 2 (mTORC1 and mTORC2) [85] mTOR is implicated in several diseases such as tuberous sclerosis (TSC), cancer, diabetics and obesity, among others [86].