For example, increased infiltration of pro-inflammatory immune cells (primarily CD8+ cytotoxic T cells) in the tumor microenvironment (TME) is associated with a good prognosis in cancer patients [1,2,3,4], whereas the presence of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), regulatory T cells, tumor-associated macrophages (TAMs) and fibroblasts have an adverse effect, reducing the efficacy in oncological treatments [5,6,7]. The gene discussed is CD8A; the disease is neoplasm.