CXCL16 and cancer: On the other hand, the changes between M0 and S + M0 were detected for chemokines CXCL12 (from 0.09 to 0.06 ng/mL, p = 0.0102), CXCL16 (from 0.58 to 0.45 ng/mL, p = 0.0012), and CCL22 (from 0.37 to 0.11 ng/mL, p = 0.0037), demonstrating the inhibitory effect of the cancer cell spheroids (Figure 5b).