Similar to reprogramming without cancer cell spheroids, macrophages began to produce Arg1hi (S + M1→M2: 34%; S + M2→M1: 37%) and IFNβ (S + M1→M2: 2.6 ng/mL; S + M2→M1: 2 ng/mL) (Figure 4c,d), but IFNα and IL-10 cytokines were not detected (Figure S3b). The gene discussed is IL10; the disease is cancer.