Various RA-associated inflammatory factors, such as IL-6, IL-8, IL-1β, IL-27, and COX-2 [18,32], RA-associated joint remodeling factor Dickkopf-1 (DKK-1) [33], and osteoclastogenesis factor receptor activator of nuclear factors κB ligand (RANKL) [34] in multiple-input-stimulated RA-FLSs with or without Dex were evaluated in a transwell culture system. The gene discussed is DKK1; the disease is rheumatoid arthritis.