Type I IFN activates STAT1 to bind to B cell lymphoma 6 (Bcl6), a transcription factor that is required for Tfh development [336], and in human and SLE mouse model, type I IFN signaling activates STAT4 to produce IL-21 and IFNγ [337]. The gene discussed is IFNG; the disease is systemic lupus erythematosus.