As a result of the H2S-dependent upregulation of the mTORC1/TrkB signaling pathway, the expression of synaptic proteins, such as PSD-95, synaptophysin, and the AMPA receptor GluR 1/2 subunit, in the hippocampus of rats with depression-like behavior, was increased [246]. This evidence concerns the gene DLG4 and depressive disorder.