HMOX2 and Cognitive impairment: In addition, H2S enhanced the Warburg effect, known as aerobic glycolysis, which promotes synaptic plasticity and has a neuroprotective effect [231], in the hippocampal cells of rats with a cognitive deficit against the background of an increase in the expression of hexokinase 2 (HO-2), pyruvate kinase M2 (M2-RK), lactate dehydrogenase A (LDH A), kinase pyruvate dehydrogenase 1 (PDK), increased levels of lactic acid, and reduced expression of pyruvate dehydrogenase (PD) (Figure 9) [232].