After cerebral ischemia-reperfusion with a survival of >6 months, both the toxic C-terminal of the amyloid protein precursor and β-amyloid peptide around the BBB vessels, developing perivascular cuffs with rarefaction of the adjacent white matter and parallel oligodendrocyte staining were noted [31,32,33,34,35,36]. The gene discussed is PPIB; the disease is brain ischemia.