PPIB and cerebral amyloid angiopathy: Abnormal BBB sealing possibly caused by the breakdown of blood purification from the β-amyloid peptide, thickening of the vascular wall, and transformation of amyloid protein precursor metabolism from non-amyloidogenic to amyloidogenic, leads to the development of cerebral amyloid angiopathy in association with the age of the patient [12,104,143].