The pharmacological inhibition of Rac1 activity by an inhibitor EHT 1864 blocks or reduces Aβ40 and Aβ42 production in cell lines endogenously expressing wild-type and human mutant APP and in Hartley albino guinea pigs (an AD model for physiological APP processing and Aβ generation), respectively [175]. The gene discussed is RAC1; the disease is Alzheimer disease.