In addition, the breakpoint cluster region (BCR) gene encoding a GAP, the family of dedicator of cytokinesis (Dock) 9 encoding a GEF, the Gem-interacting protein (GMIP) gene encoding a novel GAP, and the triple functional domain (TRIO) protein (a GEF for Rac1) is associated with bipolar disorder or MDD in subjects [193,194,195,196,197]. Here, GMIP is linked to bipolar disorder.