Considering tumor tissue from 100 patients with known HPV status and locally advanced HNSCC treated with concurrent chemo-radiotherapy (three-weekly cisplatin) or bio-radiotherapy (weekly cetuximab), Ou et al. [83] evaluated the expression level of CA-IX and the MVD determined as the density of CD34+ vascular structures. This evidence concerns the gene CD34 and head and neck squamous cell carcinoma.