To confirm the role of fibroblast growth in modulating the tumor microenvironment, Starska et al. [106] found that the fibroblast growth factor receptors, FGFR1 and FGFR3, and the pathway downstream of its regulatory kinases phosphoinositide 3-kinase (PI3K)/AKT promoted the invasiveness of cancer cells resulting in a worse prognosis of laryngeal cancer. The gene discussed is AKT1; the disease is laryngeal carcinoma.