MAT1A and metabolic dysfunction-associated steatotic liver disease: These authors identified a unique serum metabolomic profile of Mat1a (methionine adenosyltransferase 1A) knockout (KO) mice and 0.1MCD (methionine and choline deficient) model and observed, using a large cohort of serum samples from biopsied NAFLD patients, that some of them showed this metabolic signature (M-subtype), identifying those patients that will likely benefit from therapy with S-adenosylmethionine (SAMe) or Aramchol.