CASP3 and central nervous system cancer: Previous studies have demonstrated that KPF cause G2/M phase arrest, preventing migration in human gliomas cells through increased levels of IL-6, IL-8, chemokines, monocyte chemo-attractant protein-1, Bcl-2, cleaved caspase-3, -8, anti-apoptotic proteins survivin and XIAP, cleaved poly(ADP-ribose) polymerase expression, depolarization of the mitochondrial membrane potential, and rapid reduction in the phosphorylation of ERK and AKT [31,34,35].