CDKN1A and malignant colon neoplasm: As shown in the schematic diagram below (Figure 7), in normal cells, both miR-372 and p53/p21 are suppressed by the INO80 complex by regulating the chromatin structure; when the INO80 complex is silenced, it will lead to instability of the complex and loss of chromatin remodeling enzyme activity; thus, the inhibition of INO80 complex on miR-372 and p53/p21 is released, leading to the up-regulation of miR-372 and p53/p21 expression, further inhibiting the proliferation of HCT116 colon cancer cells.