However, in support of a link of the intracellular protein traffickers and 5-FU response, a report has shown that the adaptor that links the retromer to its regulator, FAM21, physically associates with several factors in the NFkB pathway and its depletion sensitized pancreatic cancer cells to the 5-FU via disruption of the chromatin association of the NFkB transcription factor [65]. Here, NFKB1 is linked to familial pancreatic carcinoma.