High expression of the BC-specific ICD-derived metagene signature (TNF/CXCR3/P2RX7/CASP1/NLRP3/IL1B/LY96/CD4+/CD8+A/CD8+B/PRF1/IFNG/IL17A/IL17RA) is associated with prolonged overall survival (OS) in BC and OC patients but not in lung cancer patients. The gene discussed is PRF1; the disease is breast cancer.