The overexpression of steroid receptor coactivator 3 (SRC-3) and tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4), activators of PI3K/AKT signaling, which is associated with a more aggressive phenotype, enrichment of CSC population, and therapy resistance, is frequently found in BC and OC [164,165,166]. This evidence concerns the gene PIK3CA and breast cancer.