CD44+/CD24−/low BCSC play a crucial role in cancer invasion, as cell lines with a higher proportion of CD44+/CD24−/low cells exhibit greater expression of pro-invasive genes, such as interleukin-1 alpha (IL1α), interleukin-6 (IL6), and interleukin-8 (IL8) [65]. Here, IL1A is linked to cancer.