In contrast, hypomethylated genes were enriched in cellular regulatory pathways, such as Ras signaling pathway, adrenergic signaling in cardiomyocytes, hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, PI3K-Akt signaling pathway, adherens junction, p53 signaling pathway, regulation of actin cytoskeleton, Rap1 signaling pathway, and FA metabolism (FDR < 0.0500; Figure 5A,B). Here, AKT1 is linked to hypertrophic cardiomyopathy.