High levels of TG-rich VLDL, and consequently increased levels of small dense LDL (sdLDL), generated by the action of hepatic lipase (HL) on TG-rich LDL particles (enriched with TG due to cholesterol ester transfer protein (CETP)-mediated transfer of TGs from TG-rich VLDL) as well as low levels of HDL (due to an increased catabolism of small dense HDL generated by CETP and HL), are hallmarks of MS dyslipidemia (reviewed in [25,26]). Here, LIPC is linked to metabolic syndrome.