Moreover, autoantibodies against vascular heparan sulfate proteoglycans (HSPG) at the vascular basement membrane [78] could reveal another important aspect of the pathophysiology of SLE since proteoglycans are proposed to be an essential medium of the extracellular matrix in the re-establishment of proper Piezo2–Piezo1 crosstalk and regeneration [16]. Here, CD44 is linked to systemic lupus erythematosus.