NFKB1 and colon carcinoma: In HT-29 human colon carcinoma cell culture, this polyphenol promoted apoptosis and reverted the epithelial-to-mesenchymal phenotype transition by downregulating expression of NF-κB and Notch-1, thus causing a decrease in expression of invasiveness-related proteins and upregulation of the expression of pro-apoptotic factors [273].