Treatment with genistein promotes acetylation of histones at the transcription start sites of p16 and p21 tumor suppressor genes in prostate (LNCaP and DuPro) [184] and breast (MDA-MB-231) [185] cancer cell cultures, and of BTG3 tumor suppressor genes in renal (A498, ACHN) [171] and prostate (LNCaP, PC3) [172] cancer cell cultures. The gene discussed is CDKN1A; the disease is cancer.