This phenolic compound was also able to suppress proliferation of human MV3 and A375 melanoma cells, both in culture and in a mouse xenograft model, by downregulating the expression of NF-κB and NF-κB-regulated miR-221, thus leading to the enhancement of the expression of TFG tumor suppressors, the mRNA of which is targeted by miR-221 [265]. This evidence concerns the gene NFKB1 and melanoma.