The binding of polyphenols to active AhR-Arnt dimer may also inhibit activation of AhR-regulated genes by preventing binding of the dimer to the XRE DNA elements: the ability of preventing binding of the dimer to the XREs in tumor cell cultures was demonstrated for resveratrol [104], curcumin [101], quercitin, kaempferol [93], and galangin [102]. This evidence concerns the gene AHR and neoplasm.