Results of treatment of MDA-MB-231 human breast cancer cell culture with genistein also suggest involvement of Notch-1 in the inhibition of the NF-κB signaling pathway by this phenolic compound, as genistein exerted antiproliferative and proapoptotic activity towards this cell culture by downregulating expression of Notch-1, accompanied by inhibition of NF-κB activation [274]. The gene discussed is NFKB1; the disease is breast cancer.