STAT3 and non-small cell lung carcinoma: The similar activity of apigenin, along with luteolin, towards KRAS-mutated non-small cell lung carcinoma cell cultures and xenografts was described: these compounds were able to prevent γ-interferon-induced upregulation of PD-L1 expression by suppressing activity of the MUC-1C/STAT3 signaling pathway; molecular docking results suggest that these polyphenols can interact directly with STAT3 molecules [339].