Moreover, Tiwari et al. and Serra et al. reported two other cases with an early-onset form of CRD that presented compound heterozygous mutations in the C2orf71 gene: p.Gly570Glufs*3 and p.Leu744Glufs*7 [53], and p.Leu288Alafs*23 and p.Cys599Arg [3], both in compound heterozygosity. This evidence concerns the gene PCARE and cone-rod dystrophy.