However, C2orf71 patients (or siblings) with the same disease-causing genotype suffer from a different RP phenotype, other IRD, or variability in disease severity with unclear correlation, in contrast to other autosomal dominant RP cases, in which there is a clear correlation between genotype and phenotype (e.g., GUCY2D [69]). The gene discussed is PCARE; the disease is retinitis pigmentosa 1.