By conducting an association analysis between C2orf71 SNPs and colorectal cancer risk in 1419 Chinese Han participants, Jiang et al. found several SNPs (C2orf71-rs17744093, -rs10200693, -rs10166913, -rs17007544, and -rs13385188) were associated with increased colorectal cancer risk [74]. This evidence concerns the gene PCARE and colorectal cancer.