Four days after lesion, calretinin optical density was reduced with respect to its control by 10.4% to 89.6 ± 2.12% in the ATD group (n = 445; Figure 2D, red column), which was significantly lower than the mean values obtained in all the other groups either control or treated (one-way ANOVA, Duncan ́s method for pairwise multiple comparisons, F(5,2162) = 15.87; p < 0.001). Here, CALB2 is linked to Jeune syndrome.