SP1 and glioblastoma: Sp1 gene expression was significantly up-regulated in the GBM tissues compared to that in normal tissues (p < 0.001; Figure 1A), and high Sp1 expression was correlated to poor survival (p = 0.043) and poor prognosis (AUC = 0.817, CI = 0.798–0.837) (Figure 1B,C).