Additionally, EZH2 has actions that induce the PI3K/AKT pathway in clinically aggressive chronic lymphocytic leukemia [46], and it modulates the cardioprotective effects of mesenchymal-stem-cell-secreted exosomes via HMGA2-mediated PI3K/AKT signaling [19]. Here, HMGA2 is linked to B-cell chronic lymphocytic leukemia.