Interestingly, a recent study highlighted the impairment of early steps of adipogenesis in type 2 diabetes, independently of obesity, by demonstrating an inverse correlation between the expression of MMP2 and AP2 in the stromal vascular fraction isolated from the abdominal subcutaneous adipose tissue of T2D obese patients vs. non-diabetic obese individuals [37]. The gene discussed is MMP2; the disease is obesity due to melanocortin 4 receptor deficiency.