Knockdown of Igfbprp1 expression in mice mitigates thioacetamide-induced hepatic fibrosis through Sonic Hedgehog (SHH)-mediated regulation of MMP2/TIMP2 and MMP9/TIMP1 balance, inhibition of hepatic stellate cell activation, decreased transforming growth factor beta (Tgf1β) expression, and degradation of the ECM [248]. The gene discussed is TIMP1; the disease is Hepatic fibrosis.