MMP2 and obesity due to melanocortin 4 receptor deficiency: Of the five MMP2 variants analyzed, two synonymous single nucleotide polymorphisms (SNPs), namely rs17242319 (Gly226Gly) (now called rs1132896 in the SNP database BUILD 129) and rs10775332 (Phe602Phe) were significantly associated with overweight/obesity.