To give strength to these data, a clinical study on patients with metabolic syndrome showed that when submitted to a regime with a high fiber/low-fat content and daily aerobic exercise for 3 weeks, their total level of serum MMP9 was significantly reduced along other markers of inflammation and oxidative stress as well as a significant decrease in circulating lipids, fasting blood glucose, insulin, and HOMA-IR index [45]. Here, INS is linked to metabolic syndrome.