In this study, it was highlighted that MMP2 may be a predictive factor of NASH even in patients with mild fibrosis since MMP2 liver expression and MMP2 serum levels were still elevated in NASH patients without advanced fibrosis whereas serum hyaluronic acid concentration was not different in these patients as compared with patients with simple steatosis [247]. Here, MMP2 is linked to metabolic dysfunction-associated steatohepatitis.