MMP13 and obesity due to melanocortin 4 receptor deficiency: Interestingly, MMP13 is more expressed in the stromal vascular fraction (SVF) than in adipocytes and this expression is exacerbated in the SVF in both GWAT and ScWAT under a HFD [109], implying the role of MMP13 in adipose tissue and ECM remodeling during obesity.