SLC4A7 and cancer: Furthermore, cell perfusion with the NaHCO3-containing Ringer slowed the pHi recovery from acid load, especially in HPDE cells (Figure 3A), demonstrating the greater involvement of NaHCO3 transporters in pHi regulation in normal cells rather than in cancer cells and supporting the observation that bicarbonate transporters are dysregulated in PDAC [8,17,18].