The genes encoding the CYP11A1 electron transport proteins (FDX1, FDXR), the enzyme involved in the metabolism of pregnenolone to DHEA (CYP17A1), and proteins that enhance the CYP17A1 17/20-lyase reaction (POR, CYB5A) [26,27,28], were also differentially expressed, with highest expression in PCOS theca cells stimulated with forskolin. This evidence concerns the gene CYB5A and polycystic ovary syndrome.