The transcription factors SREBF1, which regulates genes involved in cholesterol acquisition, and GATA6, which regulates the expression of genes encoding steroidogenic enzymes (CYP17A1, CYP11A1) in concert with other differentially expressed transcription factors, appear to play a major role in driving the PCOS theca cell molecular signature. This evidence concerns the gene CYP11A1 and polycystic ovary syndrome.