On the other hand, in Asian populations, other mutations including heterozygous mutation in the coding exon 1 of the UGT1A1 gene (such as a presence of the UGT1A1*6 allele) or other variants in the promoter UGT1A1 region (such as mutations in the phenobarbital-responsive enhancer module NR3 region (gtPBREM NR3)) may predispose patients to hyperbilirubinemia [3]. This evidence concerns the gene UGT1A1 and Hyperbilirubinemia.