Functional enrichment analysis, performed by considering WikiPathways database to evidence eventual specific ME/CFS-associated genes (Figure 3c), showed that pathways regulated by altered miRNAs were involved in extracellular matrix remodeling (matrix metalloproteinases and Focal Adhesion), cytokines-mediated signaling pathway (IL-6, Oncostatin M, IL-7, and TGF-β), apoptosis, cell-cycle regulation via the P13K-m-TOR signaling pathway, immune response to microbial infection (NOD pathway), and senescence and autophagy in pathologic conditions. Here, TGFB1 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.