Moreover, we observed an opposite effect in lung cancer patients with adenocarcinoma, the squamous cell carcinoma subtypes, and the -735CC genotype which all had statistically increased MMP-2 levels, as well as patients with the -1562CC genotype who had higher MMP-9 concentration levels than in patients with the -1562CT genotype. The gene discussed is MMP2; the disease is squamous cell carcinoma.