MMP2 and lung cancer: Individuals with the TT genotype of the MMP-2-735C/T polymorphism had a lower risk of lung cancer when compared to the CC genotype, according to Wang et al. (2012) [43], and Li et al. (2015) [24], and the TT genotype had a protective effect as a result of a lower promoter activity, and thus lowered the MMP-2 enzyme activity.