At this point, it could be expected that individuals who smoke and carry the MMP-2-735CC or -1306CC genotype, or the C-735-C-1306 haplotype, are more susceptible to develop lung cancer than those who smoke and carry either the -735TT or -1306TT genotype, or the T-735-T-1306 haplotype. The gene discussed is MMP2; the disease is lung cancer.