There was a statistically significant positive correlation between only nuclear and nuclear and cytoplasmatic HIF-1α positivity in primary LC lesions (p < 0.0001); however, when analyzing ACs and SCCs separately, this was true for SCCs (p = 0.0004), but not ACs (p = 0.1939). This evidence concerns the gene HIF1A and laryngotracheoesophageal cleft.