HIF1A and cancer: It has been shown that the dysregulation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signaling pathway, which is one of the key factors in the tumorigenesis of various malignancies, leads to GLUT1 and HIF-1α overexpressions, thus allowing these factors to influence tumor metabolism and cancer propagation [41].