SPARC and cholangiocarcinoma: Together with CD13, SPARC, and zyxin, GALC-upregulated cytoplasmic FMR1-interacting protein 1 and catenin alpha 1 are also implicated in the metastatic process by regulating cytoskeletal dynamics and cell adhesion of tumor cells [15,16], PPFIA-binding protein 1 drives tumor cell migration and invasion via the FAK/Src/JNK pathway [27], ER-associated collagen prolyl 3-hydroxylase 1 plays a pivotal role in cancer cell proliferation, migration, and invasion [25], and the lipid transporter oxysterol-binding protein has been proposed as a potential marker for cholangiocarcinoma metastasis [24].