Similarly, the cysteine-rich acidic matrix-associated protein (SPARC) plays a role in melanoma metastasis [29], whereas lectin mannose-binding 1 (LMAN1) is involved in melanoma ER stress and autophagy [21], and the expression of the zinc-binding, focal adhesion-associated phosphoprotein zyxin has been shown to affect melanoma cell spreading and proliferation [34]. The gene discussed is SPARC; the disease is melanoma.