Among them, three genes encode for proteins related to ER responses (i.e., LMAN1, SRP72, and EIF2A), three genes encode for proteins that play a significant role in the metastatic process (i.e., SPARC, CYFIP1, and PPFIBP1), and three genes encode for proteins involved in tumor immune escape (i.e., KPNA4, NT5E, and RBM12), thus supporting the role of GALC in different aspects of melanoma progression. The gene discussed is SPARC; the disease is neoplasm.