Moreover, LC-MS/MS proteomic analysis, supported by transcriptomic data mining, demonstrates for the first time that GALC upregulation exerts a significant impact on the proteomic landscape of BRAF-mutated human melanoma cells, leading to the modulation of the expression of proteins involved in different aspects of tumor progression, including endoplasmic reticulum responses, the metastatic process, and tumor immune escape. This evidence concerns the gene GALC and melanoma.