In addition, GALC upregulation causes the downregulation of the oncosuppressor aconitase 2, which affects the TCA cycle and mitochondrial oxidative metabolism in cancer cells [35,36], and of the serine protease inhibitor serpin family B member 6, whose dysregulation is associated with autophagic and apoptotic induction in cancer [37]. The gene discussed is ACO2; the disease is cancer.