In keeping with this hypothesis, Galc knockdown causes a decrease in the tumorigenic and metastatic potential of murine melanoma B16 cells that also showed significant alterations in their lipidomic profile, characterized by increased levels of the oncosuppressive sphingolipid ceramide and of diacylglycerols, mirrored by a decrease in sphingomyelins, phosphatidylethanolamines, and cholesteryl esters. Here, GALC is linked to melanoma.