In keeping with the hypothesis that GALC may modulate the energetic plasticity of melanoma cells (see above), both GALC-transduced A2058 and A375 cells are characterized by higher levels of the mitochondrial abhydrolase domain-containing 10 able to affect the mitochondrial antioxidant activity [10] and of glycogenin 1, a glycosyltransferase involved in the first steps of glycogen synthesis downregulated in liver cancers [18]. The gene discussed is GYG1; the disease is melanoma.