For GBM, the significant genes which drive the TME are phosphatase and tensin homologue (PTEN), tumor protein 53 (TP53), platelet-derived growth factor receptor-α (PDGFRA), neurofibromatosis type 1 (NF1), telomerase reverse transcriptase promoter (TERTp), and epidermal growth factor receptor (EGFR) [130,131]. Here, TP53 is linked to glioblastoma.