By inserting the gene for a special CAR receptor into the T cells, the CAR T cells (EGFRvIII-CAR, IL13Rα2-CAR, or HER2-CAR) can kill cancer cells by binding to the antigen, EGFRvIII, IL13Rα2, or HER2, that is overexpressed on GBM cells (Figure 6). The gene discussed is IL13RA2; the disease is cancer.