The colony-stimulating factor-1 (CSF1) and chemokine (C-C motif) ligand 2 (CCL2) are two major promoters for macrophage recruitment in the TME, while hypoxia can also induce the production of CSF1 and CCL2 by tumor cells, leading to the downregulation of the corresponding receptors [35]. This evidence concerns the gene CSF1 and neoplasm.