ABCG2 and malignant colon neoplasm: As shown in Figure 4, ABCG2 expression was significantly lower in colon cancer samples than in paired noncancerous tissues (p = 3.91 × 10−25) indicated by DNA chip data, and significantly lower in both colon and rectum adenocarcinoma samples compared to paired normal tissues, assessed by RNA-seq (p = 8.71 × 10−8 and p = 9.15 × 10−3, respectively).