Adding air to the subretinal tPA is supposed to have several advantages, including contribution to the displacement of the blood downwards due to its direct pushing on the blood; protection of the macular area as the subretinal air is prevented to migrate further superiorly by the presence of the intravitreal gas; maintenance of the localized retinal detachment for few days, potentially allowing a prolonged action of the tPA and, thus, enhanced blood liquefaction; and increased oxygenation to the photoreceptors [45]. Here, PLAT is linked to retinal detachment.