MRC1 and colorectal carcinoma: Subsequently, the IHC experiment demonstrated that, compared with the AOM/DSS group, the MC-LR/AOM/DSS group showed more macrophage recruitment by detecting markers of macrophages, F4/80 (Figure 4C), and more M2 macrophages infiltration in CRC tissues by detecting markers of the M2 macrophage, CD163 and CD206 (Figure 4D,E).