As a result, supplementation with a TGF-β1-neutralizing antibody in the co-culture system inhibited the migration of CRC cells, which was induced by MC-LR (Figure 3A,B), suggesting that the exposure of MC-LR enhanced the migration of CRC cells via upregulating the secretion of TGF-β1 from M2 macrophage in the co-culture system. The gene discussed is TGFB1; the disease is colorectal carcinoma.