In addition, compared with the mice of the AOM/DSS group, the level of TGF-β1 was elevated (Figure 4F) and CST3 was reduced (Figure 4G) in CRC tissues of MC-LR-treated mice, whereas the control exhibited a lower expression of TGF-β1 (Figure 4F) and higher expression of CST3 (Figure 4G) in colorectal tissues compared to that in CRC tissues of both MC-LR/AOM/DSS and AOM/DSS mice. Here, CST3 is linked to infectious otitis media.