TGFB1 and colorectal carcinoma: The results demonstrated that the protein expression of TGF-β1 in M2 macrophages was enhanced in the co-culture system after the exposure of MC-LR (Figure 2C,D, lanes 3 and 4 in M2 macrophage), and the supernatant of MC-LR-treated CRC cells also promoted the expression detected by qPCR (Figure S1F,G), while the expression in CRC cells had no obvious changes (Figure 2C,D, lanes 3 and 4 in DLD-1 and SW480), suggesting that the elevated TGF-β1 induced by MC-LR in the co-culture system was mainly secreted by M2 macrophages.