In contrast, Zhang et al. have shown that the upregulation of miR-155 could promote the migration and invasion of CRC cells through the regulation of claudin-1 expression [35], and Wan et al. indicated it as a potential contributor to the progression and growth of CRC by enhancing the Wnt/β-catenin pathway in an HMG-box-transcription-factor-1-associated mechanism [36]. This evidence concerns the gene HBP1 and colorectal carcinoma.