Moreover, uPAR+ tumor cells could modulate macrophage polarization toward the M2 phenotype through TGF-β signaling pathways after uPA-uPAR cleavage-dependent activation [19,52,53], while TGF-β induces uPA expression on cancer cells in positive feedback [52,53,54,55,56]. This evidence concerns the gene TGFB1 and neoplasm.