Our preliminary results showed that uPAR inhibition exerted a potent anti-inflammatory effect by almost abolishing IL-6 and DKK-1 secretion; in particular, DKK-1 glycoprotein, an inhibitory component of the Wnt pathway, promotes pathological type 2 cell-mediated inflammation and immune evasion and induces immunosuppressive macrophages in several cancers [74,75]. Here, DKK1 is linked to cancer.