Conversely, IL-6 (mean ± SD, 7897.99 ± 4255.5 pg/mL vs. 962.2 ± 1462.5 pg/mL, MM vs. controls; p = 0.0013 by uncorrected Fisher’s LSD test) and DKK-1 (mean ± SD, 6516.44 ± 5842.6 pg/mL vs. 1041.1 ± 652.1 pg/mL, MM vs. controls; p = 0.0073 by uncorrected Fisher’s LSD test) were significantly increased in the media MM patients after 21 days of culture compared to healthy controls (Figure 3). This evidence concerns the gene DKK1 and Miyoshi myopathy.