LGALS3 and ventricular septal defect 1: However, while some authors (Saleh et al.)have claimed that Gal-3 might perform even better than Ross classification in the precocious identification of heart failure among children with CHD, exhibiting excellent sensitivity and specificity with a cut-off value of 10.4 ng/dL, some others (Cura et al.)proved in a case–control study that enrolled infants with ventricular septal defects (VSD) that Gal-3 increases independently from left ventricular dilation [92,93].