Given its complex interaction with cytosolic proteins, as well as its ubiquitous tissular expression, Gal-3 has been proven to play a role in the development of a variety of disorders, including renal disease, cardiovascular disorders, viral infection, autoimmune diseases, neurodegenerative disorders and malignancies [9,10,11,12,13,14,15,16]. The gene discussed is LGALS3; the disease is cardiovascular disorder.