In the Aβ-induced SD rat model of AD, ginsenoside Rg2 increased the Bcl-2/Bax ratio and reduced caspase-3 activity by activating the PI3K/Akt signaling pathway, thereby reducing Aβ-induced apoptosis and improving cognitive function in a rat model of AD [229]. This evidence concerns the gene AKT1 and Alzheimer disease.